Tag Archives: Predisposing Factors

Predisposing Factors

A predisposing factor is a condition or situation that may make a person more at risk or susceptible to disease. Some ⚡ predisposing factors ⚡ include heredity, age, gender, environment, and lifestyle.

Heredity is a ⚡ predisposing factor ⚡ when a trait inherited from a parent puts an individual at risk for certain diseases. Cystic fibrosis (ICD-9: 277.00), sickle cell anemia (ICD-9: 282.60), and Down syndrome (ICD-9: 758.0) are examples of hereditary diseases related to genetic abnormalities. If hereditary risks are known, individuals can be better prepared to prevent, treat, or cope with possible problems.

Age is a risk factor related to the life cycle. For example, adenoid hyperplasia (ICD-9: 474.12), acute tonsillitis (ICD-9: 463), and otitis media (ICD-9: 382.9) are more common among children than adults. Older adults are at greater risk than younger adults for degenerative arthritis (ICD-9: 715.9) and senile dementia (ICD-9: 290.0). Elderly persons have unique problems that arise from the aging process itself. Physiological changes occur in the body systems, and some of these changes can cause functional impairment. Elderly persons experience problems with temperature extremes, have lowered resistance to disease as the result of decreased immunity, and have less physical activity tolerance.

Gender is a predisposing factor when the disease is physiologically based. For example, prostate cancer (ICD-9: 185, 198.82, 233.4) occurs only in men; ovarian cancer (ICD-9: 183, 198.6, 233.39) occurs only in women. Men have gout (ICD-9: 274.0) more frequently than do women, whereas osteoporosis (ICD-9: 733.00) is more common in women. Lung cancer (ICD-9: 162.9, 197.0, 231.2) is as prevalent in women as in men. Also, women experience heart disease as often as do men.

The environment can be a risk factor. Exposure to air, noise, and other environmental pollutants may predispose individuals to disease. For example, living close to a heavily traveled thoroughfare in a city may be a predisposition to respiratory disease.

Some geographical locations have a higher incidence of insect bites and exposure to venom. Living in rural areas where fertilizers and pesticides are ommonly used can predispose individuals to disease. Conditions and diseases once endemic to only one area of the world are crossing borders to invade an unsuspecting and unprepared society. This invasion is due largely to the increased mobility of the world’s inhabitants and population density. Even office employees may be affected by environmental or occupational health problems, as seen in carpal tunnel syndrome (ICD-9: 354.0) and eye problems that can result from heavy computer use.

Lifestyle choice may predispose some diseases. Smoking and exposure to secondhand smoke is known to be a major cause of lung cancer. Substance abuse leads to a number of illnesses. Poor nutritional choices and lack of exercise are often cited as predispositions to diseases and disorders.

Risk factors in health and disease


Health and wellbeing are affected by many factors – those linked to poor health, disability, disease or death, are known as risk factors. A risk factor is a characteristic, condition, or behaviour that increases the likelihood of getting a disease or injury. Risk factors are often presented individually, however in practice they do not occur alone. They often coexist and interact with one another. For example, physical inactivity will, over time, cause weight gain, high blood pressure and high cholesterol levels. Together, these significantly increase the chance of developing chronic heart diseases and other health related problems. Ageing populations and longer life expectancy have led to an increase in long-term (chronic), expensive-to-treat diseases and disabilities.

There is a rising demand for healthcare, placing the sector under increasing budget pressure which is not always met. It is important that we, as a society and users of healthcare systems, understand the causes and risk factors behind diseases, so that we can actively take part in available cost effective prevention and treatment programmes.

In general, risk factors can be categorised into the following groups:

  • Behavioural
  • Physiological
  • Demographic
  • Environmental
  • Genetic

These are described in more detail below.

Types of risk factors

Behavioural risk factors

Behavioural risk factors usually relate to ‘actions’ that the individual has chosen to take. They can therefore be eliminated or reduced through lifestyle or behavioural choices. Examples include:

  • smoking tobacco
  • drinking too much alcohol
  • nutritional choices
  • physical inactivity
  • spending too much time in the sun without proper protection
  • not having certain vaccinations
  • unprotected sex.

Psychological risk factors

Physiological risk factors are those relating to an individual’s body or biology. They may be influenced by a combination of genetic, lifestyle and other broad factors. Examples include:

  • being overweight or obese
  • high blood pressure
  • high blood cholesterol
  • high blood sugar (glucose).

Demographic risk factors

Demographic risk factors are those that relate to the overall population. Examples include:

  • age
  • gender
  • population subgroups, such as occupation, religion, or income.

Environmental risk factors

Environmental risk factors cover a wide range of topics such as social, economic, cultural and political factors as well as physical, chemical and biological factors. Examples include:

  • access to clean water and sanitation
  • risks in the workplace
  • air pollution
  • social settings.

Genetic risk factors

Genetic risk factors are based on an individual’s genes. Some diseases, such as cystic fibrosis and muscular dystrophy, come entirely from an individual’s ‘genetic make-up’. Many other diseases, such as asthma or diabetes, reflect the interaction between the genes of the individual and environmental factors. Other diseases, like sickle cell anaemia, are more prevalent in certain population subgroups.

Global risks for mortality and demographic factors

The number of total global deaths for any cause in 2004 was 59 million people.

The table below shows the ten most common risk factors that caused a large portion of total global deaths in 2004 according to the World Health Organisation (WHO). The top six leading risk factors are all linked to potential development of long-term diseases, such as heart disease, diabetes, and cancers.

Table: WHO numbers of the 10 leading global risks for mortality (death), 2004
Rank Risk factor  % of total deaths
 1  High blood pressure  12.8
 2  Tobacco use  8.7
 3  High blood glucose  5.8
 4  Physical inactivity  5.5
 5  Overweight and obesity  4.8
 6  High cholesterol  4.5
 7  Unprotected sex  4.0
 8  Alcohol use  3.8
 9  Childhood underweight  3.8
 10  Indoor smoke from solid fuels  3.0

The ranking seen in the table above differs if income and other demographic factors are considered.


For high and middle-income countries, the most important risk factors are those related to long-term diseases, whereas in low-income countries, factors such as childhood malnutrition and unprotected sex are much more widespread.


Risk factors also change with age. Some risk factors almost exclusively affect children such as malnutrition and indoor smoke from solid fuels. For adults, there are considerable differences depending on age:

  • Unprotected sex and addictive substances (e.g. tobacco and alcohol) account for most of the health problems in younger adults
  • Risk factors for long-term diseases and cancers mainly affect older adults.


Gender differences also exist. For example, men are much more likely to be at risk of factors associated with addictive substances. Women are prone to suffer from iron deficiency during pregnancy.

Reducing exposure to risk factors

Reducing contact (exposure) to risk factors would greatly improve global health and life expectancy by many years. This would therefore reduce healthcare costs. See also the SCORE Project fact sheet as an example of how risk factors would greatly influence health and life expectancy.

Risk Factors for Cancer

It is usually not possible to know exactly why one person develops cancer and another doesn’t. But research has shown that certain risk factors may increase a person’s chances of developing cancer. (There are also factors that are linked to a lower risk of cancer. These are sometimes called protective risk factors, or just protective factors.)

Cancer risk factors include exposure to chemicals or other substances, as well as certain behaviors. They also include things people cannot control, like age and family history. A family history of certain cancers can be a sign of a possible inherited cancer syndrome.

Most cancer risk (and protective) factors are initially identified in epidemiology studies. In these studies, scientists look at large groups of people and compare those who develop cancer with those who don’t. These studies may show that the people who develop cancer are more or less likely to behave in certain ways or to be exposed to certain substances than those who do not develop cancer.

Such studies, on their own, cannot prove that a behavior or substance causes cancer. For example, the finding could be a result of chance, or the true risk factor could be something other than the suspected risk factor. But findings of this type sometimes get attention in the media, and this can lead to wrong ideas about how cancer starts and spreads.

When many studies all point to a similar association between a potential risk factor and an increased risk of cancer, and when a possible mechanism exists that could explain how the risk factor could actually cause cancer, scientists can be more confident about the relationship between the two.

The list below includes the most-studied known or suspected risk factors for cancer. Although some of these risk factors can be avoided, others—such as growing older—cannot. Limiting your exposure to avoidable risk factors may lower your risk of developing certain cancers.

  • Age
  • Alcohol
  • Cancer-Causing Substances
  • Chronic Inflammation
  • Diet
  • Hormones
  • Immunosuppression
  • Infectious Agents
  • Obesity
  • Radiation
  • Sunlight
  • Tobacco

Risk Factors for Type 2 Diabetes

Your chances of developing type 2 diabetes depend on a combination of risk factors such as your genes and lifestyle. Although you can’t change risk factors such as family history, age, or ethnicity, you can change lifestyle risk factors around eating, physical activity, and weight. These lifestyle changes can affect your chances of developing type 2 diabetes.

Read about risk factors for type 2 diabetes below and see which ones apply to you. Taking action on the factors you can change can help you delay or prevent type 2 diabetes.

You are more likely to develop type 2 diabetes if you

  • are overweight or obese
  • are age 45 or older
  • have a family history of diabetes
  • are African American, Alaska Native, American Indian, Asian American, Hispanic/Latino, Native Hawaiian, or Pacific Islander
  • have high blood pressure
  • have a low level of HDL (“good”) cholesterol, or a high level of triglycerides
  • have a history of gestational diabetes or gave birth to a baby weighing 9 pounds or more
  • are not physically active
  • have a history of heart disease or stroke
  • have depression 
  • have polycystic ovary syndrome , also called PCOS
  • have acanthosis nigricans—dark, thick, and velvety skin around your neck or armpits

You can also take the Diabetes Risk Test to learn about your risk for type 2 diabetes.

To see if your weight puts you at risk for type 2 diabetes, find your height in the Body Mass Index (BMI) charts below. If your weight is equal to or more than the weight listed, you have a greater chance of developing the disease.

If you are not Asian American or Pacific Islander If you are Asian American If you are Pacific Islander
 At-risk BMI ≥ 25  At-risk BMI ≥ 23  At-risk BMI ≥ 26
Height Weight Height Weight Height Weight
 4’10” 119  4’10” 110  4’10” 124
 4’11” 124  4’11” 114  4’11” 128
 5’0″ 128  5’0″ 118  5’0″ 133
 5’1″ 132  5’1″ 122  5’1″ 137
 5’2″ 136  5’2″ 126  5’2″ 142
 5’3″ 141  5’3″ 130  5’3″ 146
 5’4″ 145  5’4″ 134  5’4″ 151
 5’5″  150  5’5″ 138  5’5″ 156
 5’6″ 155  5’6″ 142  5’6″ 161
 5’7″ 159  5’7″ 146  5’7″ 166
 5’8″ 164  5’8″ 151  5’8″ 171
 5’9″  169  5’9″ 155  5’9″ 176
 5’10”  174  5’10” 160  5’10” 181
 5’11”  179  5’11” 165  5’11” 186
 6’0″  184  6’0″ 169  6’0″ 191
 6’1″  189  6’1″ 174  6’1″ 197
 6’2″  194  6’2″ 179  6’2″ 202
 6’3″  200  6’3″ 184  6’3″ 208
 6’4″  205  6’4″ 189 6’4″ 213

What can I do to prevent type 2 diabetes?

You can take steps to help prevent or delay type 2 diabetes by losing weight if you are overweight, eating fewer calories, and being more physically active. Talk with your health care professional about any of the health conditions listed above that may require medical treatment. Managing these health problems may help reduce your chances of developing type 2 diabetes. Also, ask your health care professional about any medicines you take that might increase your risk.

Asthma Risk Factors

The most common risk factors for developing asthma is having a parent with asthma, having frequent respiratory infections as a child, having an allergic condition, or being exposed to certain chemical irritants or industrial dusts in the workplace.

What puts people at risk for developing asthma?

  • Family history
    If you have a parent with asthma, you are three to six times more likely to develop asthma than someone who does not have a parent with asthma.
  • Viral respiratory infections
    Respiratory problems during infancy and childhood can cause wheezing. Some children who experience viral respiratory infections go on to develop chronic asthma.
  • Allergies
    Having an allergic condition, such as atopic dermatitis (eczema) or allergic rhinitis (hay fever), is a risk factor for developing asthma.
  • Occupational exposures
    If you have asthma, exposures to certain elements in the workplace can cause of asthma symptoms. And, for some people, exposure to certain dusts (industrial or wood dusts), chemical fumes and vapors, and molds can cause asthma to develop for the very first time.
  • Smoking
    Cigarette smoke irritates the airways. Smokers have a high risk of asthma. Those whose mothers smoked during pregnancy or who were exposed to secondhand smoke are also more likely to have asthma.
  • Air Pollution
    The main component of smog (ozone) exposure raises the risk for asthma. Those who grew up or live in urban areas have a higher risk for asthma.
  • Obesity
    Children and adults who are overweight or obese are at a greater risk of asthma. Although the reasons are unclear, some experts point to low-grade inflammation in the body that occurs with extra weight. Obese patients often use more medications, suffer worse symptoms and are less able to control their asthma than patients in a healthy weight range.